cephalothin sodium /sef′əlō″thin/ , a parenteral first-generation cephalosporin antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of infections caused by susceptible bacterial strains causing respiratory, genitourinary, gastrointestinal, skin and soft tissue, and bone and joint infections, or septicemia. It is effective against many gram-positive bacilli and cocci (other than enterococcus) and some gram-negative bacilli. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or to any cephalosporin medication prohibits its use. It is prescribed with caution for patients who are allergic to penicillin. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are pain at the site of injection and hypersensitivity reactions.