cellulitis /sel′yəlī″tis/ [L, cellula, little cell; Gk, itis, inflammation] , a diffuse, acute bacterial infection of the skin and subcutaneous tissue characterized most commonly by local heat, redness, pain, and swelling and occasionally by fever, malaise, chills, and headache. Abscess and tissue destruction usually follow if antibiotics are not taken. The infection is more likely to develop in the presence of damaged skin, poor circulation, or diabetes mellitus. In addition to appropriate antibiotics, treatment includes warm soaks, elevation, and prevention of pressure to the affected areas.