calfactant, a natural lung surfactant extract. ▪ INDICATIONS: It is used in the prevention and treatment (rescue) of respiratory distress syndrome in premature infants. ▪ CONTRAINDICATIONS: No contraindications are known at present. ▪ ADVERSE EFFECTS: Concurrent illnesses that have occurred during treatment with this drug include pulmonary air leaks, pulmonary interstitial emphysema, apnea, pulmonary hemorrhage, patent ductus arteriosus, intracranial hemorrhage, severe intracranial hemorrhage, necrotizing enterocolitis, posttreatment sepsis, and posttreatment infection. Other serious adverse effects include bradycardia, oxygen desaturation, vasoconstriction, hypotension, and hypertension.
