butoconazole nitrate /byo̅o̅′təkō″nəzōl/ , an intravaginal antifungal cream. ▪ INDICATIONS: It is prescribed for the treatment of vulvovaginal fungal infections caused by Candida species. ▪ CONTRAINDICATIONS: Its use is contraindicated during the first trimester of a pregnancy. ▪ ADVERSE EFFECTS: Adverse reactions include vulvar and vaginal burning and itching.