busPIRone hydrochloride /bo͝ospir″ōn/ , an antianxiety agent not related chemically to others. Administered orally as the hydrochloride salt. Unlike benzodiazepines, does cause sedation, has low abuse potential, takes several days to weeks to exert its effect, and does not intensify the effects of other CNS depressants. ▪ INDICATIONS: It is prescribed for generalized anxiety disorders. ▪ CONTRAINDICATIONS: This drug is contraindicated in patients with severe hepatic or renal impairment. Patients taking a benzodiazepine drug should be gradually withdrawn from that medication before starting therapy with buspirone. ▪ ADVERSE EFFECTS: Among adverse reactions reported are dizziness, headache, light-headedness, excitement, and nausea.
