Budd-Chiari syndrome /bud″kē·är″ē/ [George Budd, English physician, 1808–1882; Hans Chiari, Czech-French pathologist, 1851–1916] , a disorder of hepatic circulation, marked by occlusion of the hepatic veins, that leads to liver enlargement, ascites, extensive development of collateral vessels, and severe portal hypertension. It may be congenital. Also called Chiari’s syndrome, Rokitansky’s disease.