bortezomib, a miscellaneous antineoplastic. ▪ INDICATIONS: This drug is used to treat multiple myeloma when at least two other treatments have failed. ▪ CONTRAINDICATIONS: Pregnancy and known hypersensitivity to this drug, boron, or mannitol prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include hypotension, edema, anemia, fatigue, malaise, weakness, arthralgia, bone pain, muscle cramps, myalgia, back pain, abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting, anorexia, anxiety, insomnia, dizziness, headache, peripheral neuropathy, rigors, paresthesia, cough, pneumonia, dyspnea, upper respiratory infection, dehydration, weight loss, herpes zoster, rash, pruritus, and blurred vision. Life-threatening side effects include neutropenia and thrombocytopenia.
