bleomycin sulfate /blē·əmī″sin/ , an antineoplastic antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of a variety of neoplasms. ▪ CONTRAINDICATIONS: Hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are pneumonitis, pulmonary fibrosis, and a syndrome of hyperpyrexia and circulatory collapse. Rashes and skin reactions commonly occur.