bicalutamide, an anticancer chemotherapy agent. ▪ INDICATIONS: It is prescribed in the treatment of metastatic prostate cancer. The drug acts by binding to androgen receptors within target cells, preventing androgens from binding to them. ▪ CONTRAINDICATIONS: The drug should not be given to patients who have an allergic reaction to it. Bicalutamide should be used with caution in patients with moderate to severe liver dysfunction. ▪ ADVERSE EFFECTS: The side effects most often reported include hot flashes, general body pain, asthenia, constipation, nausea, and diarrhea.