Zollinger-Ellison syndrome /zol″injər el″isən/ [Robert M. Zollinger, American surgeon, 1903–1992; Edwin H. Ellison, American physician, 1918–1970] , a condition in which tumors in the pancreas produce excessive amounts of gastrin, which in turn increases the production of gastric acid, leading to gastric ulcers. See also peptic ulcer. ▪ OBSERVATIONS: The condition is characterized by severe peptic ulceration, gastric hypersecretion, elevated serum gastrin, and gastrinoma of the pancreas or the duodenum. Severe abdominal pain, bloating, gastrointestinal bleeding, and anemia are common symptoms. ▪ INTERVENTIONS: The administration of proton pump inhibitors is usually effective in reducing excess gastric secretions. Surgery may be required if complications occur related to the peptic ulcers. The tumors producing gastrin are often difficult to remove, or they may be so numerous that this procedure is ineffective. However, removal or ablation may be considered. ▪ PATIENT CARE CONSIDERATIONS: The syndrome is uncommon and may occur in early childhood but is seen more frequently in people between 20 and 50 years of age. Two thirds of the tumors are malignant. Careful monitoring and follow-up are essential.
