Walker-Warburg syndrome /waw′kər·vär′bo͝org/ [Arthur Earl Walker, American surgeon, b. 1907; Mette Warburg, 20th-century Danish ophthalmologist] , a congenital syndrome, usually fatal before the age of 1 year, consisting of hydrocephalus, agyria, various ocular anomalies such as retinal dysplasia, corneal opacity, or microphthalmia, and sometimes encephalocele. Also called HARD syndrome, Walker’s lissencephaly, Warburg’s syndrome.