troleandomycin /trol′ē·an′dōmī″sin/ , a macrolide antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of certain infections, including pneumococcal pneumonia and group A streptococcal infections of the upper respiratory tract. It has orphan drug status for the treatment of corticosteroid-dependent asthma due to its steroid-sparing properties. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or concomitant use of ergot alkaloids prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are GI disturbances, mild to severe allergic reactions (including anaphylaxis), and hepatotoxicity.
