topotecan, an antineoplastic hormone. ▪ INDICATIONS: It is used to treat metastatic carcinoma of the ovary after failure of traditional chemotherapy. ▪ CONTRAINDICATIONS: Factors that prohibit the use of this drug are known hypersensitivity, lactation, and severe bone marrow depression. ▪ ADVERSE EFFECTS: Life-threatening effects are neutropenia, leukopenia, thrombocytopenia, anemia, and sepsis. Other adverse effects are abdominal pain, constipation, diarrhea, obstruction, nausea, stomatitis, vomiting, increased alanine aminotransferase and aspartate aminotransferase, anorexia, arthralgia, asthenia, headache, myalgia, pain, dyspnea, and total alopecia.
