tolcapone, an antiparkinsonian agent. ▪ INDICATIONS: It is used in the treatment of parkinsonism. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects include hemolytic anemia, leukopenia, and agranulocytosis. Other adverse reactions include dystonia, dyskinesia, dreaming, psychosis, hallucinations, dizziness, chest pain, hypotension, cataract, eye inflammation, diarrhea, constipation, urinary tract infection, urine discoloration, uterine tumor, micturition disorder, sweating, and alopecia. Common side effects include fatigue, headache, confusion, orthostatic hypotension, nausea, vomiting, anorexia, and abdominal distress.
