TOLBUTamide /tolbo̅o̅′təmīd/ , an oral sulfonylurea antidiabetic. ▪ INDICATIONS: It is prescribed in the treatment of stable type 2 diabetes uncontrolled by diet alone and for some patients changing from insulin to oral therapy. ▪ CONTRAINDICATIONS: Unstable diabetes, serious impairment of renal, hepatic, or thyroid function, pregnancy, or known hypersensitivity to this drug or to other sulfonylurea medications prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are hypoglycemia and skin reactions. Blood dyscrasias may occur.
