tiludronate, a parathyroid agent (calcium regulator). ▪ INDICATIONS: It is used to treat Paget’s disease. ▪ CONTRAINDICATIONS: Factors that prohibit its use include known hypersensitivity to biphosphonates, pathological fractures, colitis, and severe renal disease with creatinine 5 mg/dL. Its use is also contraindicated in children. ▪ ADVERSE EFFECTS: Adverse effects include dry mouth, gastritis, vomiting, flatulence, gastric ulcers, rhinitis, rales, sinusitis, upper respiratory infection, headache, somnolence, dizziness, anxiety, vertigo, nervousness, involuntary movements, hyperparathyroidism, rash, epidermal necrosis, pruritus, sweating, nephrotoxicity, decreased mineralization of nonaffected bones, and pathological fractures. Common side effects include nausea, diarrhea, and bone pain.
