temozolomide, a miscellaneous antineoplastic agent. ▪ INDICATIONS: It is used to treat anaplastic astrocytoma with relapse. ▪ CONTRAINDICATIONS: Pregnancy, lactation, and known hypersensitivity to this drug or to carbazine prohibit its use. ▪ ADVERSE EFFECTS: Life-threatening effects are thrombocytopenia, leukopenia, and seizures. Other adverse effects include anemia, urinary incontinence, urinary tract infection, urinary frequency, upper respiratory infection, pharyngitis, sinusitis, cough, headache, fatigue, asthenia, fever, edema, back pain, weight increase, and diplopia. Common side effects include nausea, anorexia, vomiting, hemiparesis, dizziness, poor coordination, amnesia, insomnia, paresthesia, somnolence, paresis, ataxia, anxiety, dysphagia, depression, confusion, rash, and pruritus.
