acetoHEXAMIDE /-hek″səmīd/ , a first-generation sulfonylurea oral antidiabetic. ▪ INDICATIONS: It may be prescribed in the treatment of type 2 diabetes mellitus. ▪ CONTRAINDICATIONS: Its use is prohibited as sole therapy in type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney dysfunction, or known hypersensitivity to this drug or to other sulfonylureas. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are blood dyscrasias, hypoglycemia, and allergic reactions. GI disturbances are common.
