acetaZOLAMIDE /as′ətəzō″ləmīd/ , a carbonic anhydrase inhibitor diuretic agent. ▪ INDICATIONS: It is prescribed for the treatment for glaucoma and edema and as an adjunctive agent for the treatment of refractory epilepsy and altitude sickness. ▪ CONTRAINDICATIONS: Hyponatremia, hypokalemia, severe liver or kidney disease or dysfunction, Addison’s disease, and known hypersensitivity to this drug or other sulfonamides prohibit its use. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are anorexia and depression, particularly in the elderly; acidosis; hyperuricemia; and crystalluria. Paresthesias, GI disturbances, and lethargy are common.
