sunitinib, a miscellaneous antineoplastic. ▪ INDICATIONS: This drug is used to treat advanced renal carcinoma and GI stromal tumors after disease progression or intolerance to imatinib. ▪ CONTRAINDICATIONS: Pregnancy, lactation, and known hypersensitivity to this drug prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include headache, dizziness, insomnia, fatigue, hypertension, altered taste, constipation, stomatitis, mucositis, skin discoloration, depigmentation of hair or skin, alopecia, pain, arthralgia, myalgia, cough, dyspnea, and electrolyte abnormalities. Life-threatening side effects include central nervous system hemorrhage, seizures, left ventricular dysfunction, hepatotoxicity, vomiting, dyspepsia, pancreatitis, neutropenia, thrombocytopenia, and bleeding. Common side effects include nausea, anorexia, abdominal pain, and rash.
