splenectomy /splənek″təmē/ [Gk, splen + ektomē, excision] , the surgical removal of the spleen. The spleen is a major phagocytic organ of the reticuloendothelial network and also serves as an important site of antibody production. Infections may follow its removal because the organ plays a vital role in the body’s immune system. Splenectomized patients are particularly prone to certain bacterial infections.