Shy-Drager syndrome /shī″ drā″gər/ [G. Milton Shy, American neurologist, 1919–1967; Glenn A. Drager, American physician, b. 1917] , a rare progressive neurological disorder of young and middle-aged adults. It is characterized by orthostatic hypotension, bladder and bowel incontinence, atrophy of the iris, anhidrosis, tremor, rigidity, incoordination, ataxia, and muscle wasting. Treatment includes drug therapy to control motor symptoms and to maintain adequate blood pressure. Antigravity stockings may prevent pooling of blood in the lower extremities. See also orthostatic hypotension.