Abadie’s sign /āb’ə-dēz’/ [Jean Marie Charles Abadie, French physician, 1842–1932] , 1. spasm of the muscle that raises the upper eyelid, seen in patients with exophthalmic goiter. 2. loss of feeling in the Achilles tendon, associated with the progressive loss of deep tendon reflexes, as seen in diabetes mellitus or syphilis.