Schilder’s disease /shil″dərz/ [Paul F. Schilder, Austrian neurologist, 1886–1940] , a group of progressive severe neurological diseases beginning in childhood. All are characterized by demyelination of the white matter of the brain, with muscle spasticity, optic neuritis, aphasia, deafness, adrenal insufficiency, and dementia. Many of the signs resemble those of multiple sclerosis. Also called encephalitis periaxialis diffusa, Flatau-Schilder disease, progressive subcortical encephalopathy, Schilder’s encephalitis. See also adrenoleukodystrophy.
