scalp medication, 1. a cream, ointment, lotion, or shampoo used to treat dermatological conditions of the scalp. 2. the application of a medication to the scalp. If a cream, ointment, or lotion is to be applied, a shampoo is usually given first. The hair is dried, combed, and parted in the middle. The medication is most often spread with the fingertips. After treatment the medication may need to be washed off the scalp and hair with an alkaline shampoo. On occasion the affected area may be sharply circumscribed and may not require the scalpwide process.