reserpine /res″ərpēn/ , a depleter of biogenic amines (e.g., norepinephrine, dopamine) from nerve terminals. ▪ INDICATIONS: It is prescribed in the treatment of mild to moderate high blood pressure and has unlabeled uses for tardive dyskinesia and certain neuropsychiatric disorders. ▪ CONTRAINDICATIONS: Mental depression, peptic ulcer, ulcerative colitis, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are mental depression, extrapyramidal effects, impotence, aggravation of peptic ulcer, and paradoxical excitement.
