raloxifene, a selective estrogen receptor modulator. ▪ INDICATIONS: It is used to prevent osteoporosis in postmenopausal women. ▪ CONTRAINDICATIONS: Pregnancy, lactation, and known hypersensitivity to raloxifene prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects include insomnia, migraines, depression, hot flashes, diarrhea, anorexia, cramps, vaginitis, urinary tract infection, leukorrhea, endometrial disorder, breast pain, rash, sweating, weight gain, peripheral edema, arthralgia, myalgia, leg cramps, arthritis, sinusitis, pharyngitis, increased cough, pneumonia, and laryngitis. Nausea is a common side effect.