22q11.2 deletion syndrome, a disorder caused by a microdeletion of chromosome 22 with a wide variety of presenting signs and symptoms. Formerly called DiGeorge’s syndrome. ▪ OBSERVATIONS: Symptoms frequently noted include attention deficit hyperactivity disorder, autism, or other behavioral problems. Cleft palate is often present, as are heart defects. Cognitive and speech delays may be present. The missing section of chromosome 22 can affect every body system. ▪ INTERVENTIONS: There is no cure for the syndrome, but there are numerous treatments and therapies that can help the individual have a good quality of life. The earlier treatment is initiated, the more effective it will be. ▪ PATIENT CARE CONSIDERATIONS: Most individuals with the deletion syndrome do well, especially if appropriate treatment is initiated promptly.
