pioglitazone, an oral antidiabetic. ▪ INDICATIONS: It is used to treat stable type 2 diabetes mellitus. ▪ CONTRAINDICATIONS: Lactation, diabetic ketoacidosis, and known hypersensitivity to this drug prohibit its use. It is also contraindicated in children. ▪ ADVERSE EFFECTS: Common adverse effects include myalgia, sinusitis, upper respiratory infection, pharyngitis, headache, and aggravated diabetes mellitus.