picornavirus /pīkôr′nəvī″rəs/ [It, pico, small; RNA, ribonucleic acid; L, virus, poison] , a member of a group of small ribonucleic acid (RNA) viruses that are ether-resistant. The two main genera are Enterovirus and Rhinovirus. These viruses cause poliomyelitis, herpangina, aseptic meningitis, encephalomyocarditis, and foot-and-mouth disease.