Peyronie’s disease /pārōnēz″/ [François de la Peyronie, French physician, 1678–1747] , a disease of unknown cause resulting in fibrous induration of the corpora cavernosa of the penis. An association with Dupuytren’s contracture of the palm has been recognized. The chief symptom of Peyronie’s disease is painful erection. Palliative treatment includes radiation therapy and intralesional corticosteroid injections. There is no known cure.