pertussis vaccine, an active immunizing agent. ▪ INDICATIONS: It is prescribed for immunization against pertussis when the administration of diphtheria, pertussis, and tetanus vaccine is contraindicated. ▪ CONTRAINDICATIONS: Thrombocytopenia or known hypersensitivity to the vaccine prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are severe allergic reactions, pain and induration at the site of injection, and fever.