perphenazine /pərfen″əzēn/ , a phenothiazine derivative used as an antipsychotic and antiemetic/antivertigo agent. ▪ INDICATIONS: It is prescribed in the treatment of schizophrenia and in the control of severe nausea and vomiting in adults. Unlabeled uses include treatment of ethanol withdrawal, Huntington’s chorea, Tourette’s syndrome, spasmodic torticollis, and dementia in the elderly. ▪ CONTRAINDICATIONS: Parkinson’s disease, the concurrent administration of central nervous system depressants, liver or renal dysfunction, severe hypotension, bone marrow depression, blood dyscrasias, or known hypersensitivity to any phenothiazine prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are hypotension, liver toxicity, extrapyramidal reactions, blood dyscrasias, and hypersensitivity reactions.
