aprepitant, an antiemetic agent. ▪ INDICATIONS: This drug is used to prevent nausea and vomiting associated with cancer chemotherapy (including high-dose cisplatin). It is used in combination with other antiemetics. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include insomnia, anxiety, depression, confusion, peripheral neuropathy, bradycardia, deep vein thrombosis, hypertension, abdominal pain, anorexia, gastritis, vomiting, heartburn, serum creatine, proteinuria, dysuria, anemia, asthenia, fatigue, dehydration, fever, hiccups, tinnitus, and increased aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen. Life-threatening side effects include thrombocytopenia and neutropenia. Common side effects include headache, dizziness, diarrhea, constipation, and nausea.
