paromomycin sulfate /per′əmōmī″sin/ , an oral antiamebic aminoglycoside antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of intestinal amebiasis, tapeworms, and Cryptosporidium, and is used preoperatively to suppress intestinal flora. ▪ CONTRAINDICATIONS: Intestinal inflammation, intestinal obstruction, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious effects are GI distress and diarrhea. Less common adverse effects include headache, vertigo, and pruritus.