Papillon-Lefèvre syndrome /pä′pēyôN′ lə·fev′rə/ [M.M. Papillon, 20th-century French dermatologist; Paul Lefèvre, 20th-century French dermatologist] , an autosomal-recessive disorder occurring between the first and fifth years of life, characterized by palmoplantar keratoderma resembling psoriasis, which may also involve the elbows, knees, tibias, external malleoli, and other areas; ectopic calcifications of the skull; and periodontitis and premature shedding of both the primary and secondary teeth.
