oxacillin sodium /ok′səsil″in/ , a semisynthetic, penicillinase-resistant penicillin antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of severe bacterial infections caused by penicillinase-producing staphylococci. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or to any other penicillin prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious effects are anaphylaxis and other less severe allergic reactions, GI disturbances, and pruritus ani and vulvae.