norepinephrine bitartrate, a commercial preparation of an endogenous agonist of alpha-1, alpha-2, and beta-1 adrenergic. ▪ INDICATIONS: It is prescribed in the treatment of shock that persists after hypovolemia has been corrected. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or bisulfite preservatives prohibits its use. Hypovolemia and vascular thrombosis are contraindications unless it is used as a short-term lifesaving procedure to maintain perfusion of vital organs. It is not used in conjunction with cyclopropane or halothane anesthesia because of the increased risk of arrhythmia. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are local tissue necrosis at the site of injection, bradycardia, and headache. Overdosage can cause hypertension, peripheral or cardiac ischemia or infarctions, hemorrhagic strokes, and convulsions.
