monobenzone /-ben″zōn/ , a depigmenting agent. ▪ INDICATIONS: It is prescribed in final depigmentation in extensive vitiligo. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: The most serious adverse effect is excessive and irreversible hypopigmentation. Common effects are irritation and allergic reactions of the skin.