mitotane /mī″tətān/ , an antineoplastic that destroys normal and neoplastic adrenal cortical cells. ▪ INDICATIONS: It is prescribed in the treatment of carcinoma of the adrenal cortex and has an unlabeled use for treating Cushing’s syndrome. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug is the only contraindication. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are GI symptoms, lethargy, and adrenal insufficiency.
