Miller’s syndrome /mil′ər/ [Marvin Miller, 20th-century American pediatrician] , a syndrome of extensive facial and limb defects, characterized by malar hypoplasia, downslanting palpebral fissures, micrognathia, cleft lip and palate, cup-shaped ears, lower lid ectropion, postaxial limb deficiencies, and syndactyly. Less frequently present are heart defects and hearing loss. The syndrome is probably an autosomal-recessive trait. Also called postaxial acrofacial dysostosis.