miconazole nitrate /mīkon″əzōl/ , an antifungal drug. ▪ INDICATIONS: It is used topically to treat certain fungal infections of the skin and vagina. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects to topical or vaginal application are irritation, burning, and maceration of the skin.