metoclopramide hydrochloride /met′əklō″prəmīd/ , a GI motility agent. ▪ INDICATIONS: It is prescribed to stimulate motility of and increase the tone of gastric contractions of the upper GI tract and to prevent emesis. ▪ CONTRAINDICATIONS: A history of seizures; concomitant use of drugs that cause extrapyramidal reactions; pheochromocytoma; GI hemorrhage, obstruction, or perforation; or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are extrapyramidal reactions, usually in children, and GI disturbances. Drowsiness and allergic reactions and rash also may occur.
