methazolamide /meth′əzō″ləmīd/ , a carbonic anhydrase inhibitor. ▪ INDICATIONS: It is prescribed in the treatment of glaucoma. ▪ CONTRAINDICATIONS: Severe kidney or liver dysfunction, hyponatremia, hypokalemia, Addison’s disease, severe pulmonary obstruction, adrenocortical insufficiency, marked kidney or liver dysfunction, or known hypersensitivity to this drug or many other sulfonamides prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are malaise, aplastic anemia, drowsiness, paresthesia, hypersensitivity reactions, and acidosis.
