anistreplase, a plasminogen activator. ▪ INDICATIONS: This drug is used in acute MI for lysis of coronary artery thrombi. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or streptokinase; active internal bleeding; intraspinal or intracranial surgery; central nervous system neoplasms; severe, uncontrolled hypertension; cerebral embolism; thrombosis; hemorrhage; recent trauma; or history of cerebrovascular accident all prohibit the use of this drug. ▪ ADVERSE EFFECTS: Adverse effects of this drug include headache, fever, sweating, agitation, dizziness, paresthesia, tremor, vertigo, hypotension, conduction disorders, nausea, vomiting, decreased hematocrit, surface bleeding, rash, urticaria, phlebitis at the injection site, itching, flushing, low back pain, arthralgia, altered respirations, and dyspnea. Life-threatening side effects include intracranial hemorrhage, dysrhythmias, GI bleeding, genitourinary bleeding, intracranial bleeding, retroperitoneal bleeding, thrombocytopenia, bronchospasm, lung edema, and anaphylaxis.
