Lennox-Gastaut syndrome /len″oks-gästō″/ [William G. Lennox, American neurologist, 1884–1960; Henri Gastaut, French biologist, b. 1914] , a condition in which a variety of generalized seizures, such as tonic, atonic, absence, tonic-clonic, akinetic, and myoclonic, begin to appear in the first 5 years of life. Seizures are often intractable and may require multiple antiepileptic medications. Cognitive impairment is often present. Among suggested causes are inherited metabolic abnormalities and perinatal or postnatal disorders. Also called Gastaut’s disease.
