lamivudine (3TC) /lämiv′udēn/ , a nucleoside analog that inhibits reverse transcriptase and is used as an antiviral agent in treatment of hepatitis B infection and, in combination with zidovudine, in treatment of HIV infection and AIDS. Administered orally. ▪ INDICATIONS: The Epivir brand name form of this drug is used to treat HIV infection in combination with zidovudine. The Epivir-HBV brand name form is used to treat hepatitis B. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects are neutropenia, anemia, thrombocytopenia, and pediatric pancreatitis. Other adverse effects are anorexia, cramps, dyspepsia, taste change, hearing loss, and photophobia. Common side effects are fever, headache, malaise, dizziness, insomnia, depression, fatigue, chills, nausea, vomiting, diarrhea, cough, rash, myalgia, arthralgia, and musculoskeletal pain.
