knot /not/ [AS, cnotta] , 1. (in surgery) the interlacing of the ends of a ligature or suture so that they remain in place without slipping or becoming detached. The ends of the suture are passed twice around each other before being pulled taut to form a simple surgeon’s knot. For additional stability, the ends may be recrossed and a second simple knot made over the first. 2. (Informal) the site of a muscle spasm.