kanamycin sulfate, an aminoglycoside antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of certain severe infections (especially those caused by gram-negative aerobes) and as second-line therapy for tuberculosis. ▪ CONTRAINDICATIONS: Concomitant administration of ototoxic drugs or known hypersensitivity to this drug or to other aminoglycoside antibiotics prohibits its use. It is used with caution in patients having impaired renal function and in the elderly. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are nephrotoxicity, vestibular and auditory ototoxicity, neuromuscular blockade, and hypersensitivity reactions.
