anagrelide, an antiplatelet agent. ▪ INDICATIONS: This drug is prescribed for essential thrombocythemia. ▪ CONTRAINDICATIONS: Known hypersensitivity and hypotension prohibit its use. ▪ ADVERSE EFFECTS: Life-threatening effects include congestive heart failure, myocardial infarction, myocardiopathy, cardiomegaly, complete heart block, atrial fibrillation, anemia, thrombocytopenia, ecchymosis, and lymphadenoma. Other serious effects include tachycardia, palpitations, arrhythmia, and seizures. Common side effects include orthostatic hypotension and rash.